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Submissions from 2014

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An Abundant Dysfunctional Apolipoprotein A1 in Human Atheroma, Ying Huang, Joseph A. DiDonato, Bruce S. Levison, Dave Schmitt, Lin Li, Yuping Wu, Jennifer Buffa, Timothy Kim, Gary S. Gerstenecker, Xiaodong Gu, Chandra S. Kadiyala, Zeneng Wang, Miranda K. Culley, Jennie E. Hazen, Anthony J. DiDonato, Xiaoming Fu, Stela Z. Berisha, Daoquan Peng, Truc T. Nguyen, Shaohong Liang, Chia-Chi Chuang, Leslie Cho, Edward F. Plow, Paul L. Fox, Valentin Gogonea, W.H. Wilson Tang, John S. Parks, Edward A. Fisher, Jonathan D. Smith, and Stanley L. Hazen

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Liposome Surface Functionalization Based on Different Anchoring Lipids via Staudinger Ligation, Pratima Vabbilisetty and Xue-Long Sun

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BSA–Boronic Acid Conjugate as Lectin Mimetics, Satya Nandana Narla, Poornima Pinnamaneni, Huan Nie, Yu Li, and Xue-Long Sun

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Development of A Liquid Chromatographic Method for Quantitative Determination of Triapine, A Ribonucleotide Reductase Inhibitor, by Spectrophotometric Study of Triapine Complexation Reaction, Ye Feng, Melissa McCulloch, and Yan Xu

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Glyco-modification of Protein with O-cyanate Chain-end Functionalized Glycopolymer via Isourea Bond Formation, Valentinas Gruzdys, Hailong Zhang, and Xue-Long Sun

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Synthesis and Evaluation of Some New Aza-B-Homocholestane Derivatives as Anticancer Agents, Yanmin Huang, Jianguo Cui, Sijing Chen, Qifu Lin, Huacan Song, Chunfang Gan, Bin Su, and Aimin Zhou

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A Kinetic Analysis of The Inhibition of FOX-4 β-Lactamase, A Plasmid-Mediated AmpC Cephalosporinase, By Monocyclic β-lactams and Carbapenems, Krisztina M. Papp-Wallace, Susana Mallo, Christopher R. Bethel, Magdalena A. Taracila, Andrea M. Hujer, Ana Fernandez, Julian A. Gatta, Kerri M. Smith, Yan Xu, Malcolm G.P. Page, Eric Desarbre, German Bou, and Robert A. Bonomo

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Quantification of Free Sialic Acid in Human Plasma through a Robust Quinoxalinone Derivatization and LC–MS/MS Using Isotope-labeled Standard Calibration, Dan Wang, Xiang Zhou, Lin Wang, Sihe Wang, and Xue-Long Sun

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Systematic Investigation of Quinoxaline Derivatization of Sialic Acids and Their Quantitation Applicability Using High Performance Liquid Chromatography, Libo Wang, Dan Wang, Xiang Zhou, Lijun Wu, and Xue-Long Sun

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Primary Arylamine-based Tyrosine-targeted Protein Modification, Lin Wang, Valentinas Gruzdys, Nan Pang, Fanhao Meng, and Xue-Long Sun

Submissions from 2013

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β-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of An Unprecedented Stabilized Acyl-Enzyme, Elizabeth A. Rodkey, David C. Mcleod, Christopher R. Bethel, Kerri M. Smith, Yan Xu, Weirui Chai, Tao Che, Paul R. Carey, Robert A. Bonomo, Focco van den Akker, and John D. Buynak

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Lack of RNase L Attenuates Macrophage Functions, Xin Yi, Chun Zeng, Hongli Liu, Xiaoli Chen, Ping Zhang, Boo Seok Yun, Ge Jin, and Aimin Zhou

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Can Inhibitor-Resistant Substitutions in The Mycobacterium Tuberculosis β-Lactamase BlaC Lead to Clavulanate Resistance?: A Biochemical Rationale for The Use of β-Lactam–β-Lactamase Inhibitor Combinations, Sebastian G. Kurz, Kerstin A. Wolff, Saugata Hazra, Christopher R. Bethel, Andrea M. Hujer, Kerri M. Smith, Yan Xu, Lee W. Tremblay, John S. Blanchard, Liem Nguyen, and Robert A. Bonomo

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Cyclometalated Iridium(III) Complexes with Deoxyribose Substituents, Ayan Maity, Jung-Suk Choi, Thomas S. Teets, Nihal Deligonul, Anthony J. Berdis, and Thomas G. Gray

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A Comparative Study of Antitumor Activities and DNA Cleavage On A Class of Dehydroabietylamine Derivatives, Chao Xiang Liu, Zhong Xiang Lin, Xing Yu, Zhou Lu, Aimin Zhou, and Yong Li Bao

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Function and Distribution of Apolipoprotein A1 in The Artery Wall Are Markedly Distinct From Those in Plasma, Joseph A. DiDonato, Ying Huang, Kulwant S. Aulak, Orli Even-Or, Gary Gerstenecker, Valentin Gogonea, Yuping Wu, Paul L. Fox, W.H. Wilson Tang, Edward F. Plow, Jonathan D. Smith, Edward A. Fisher, and Stanley L. Hazen

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Myeloperoxidase, Paraoxonase-1, and HDL Form A Functional Ternary Complex, Ying Huang, Zhiping Wu, Meliana Riwanto, Shengqiang Gao, Bruce S. Levison, Xiaodong Gu, Xiaoming Fu, Matthew A. Wagner, Christian Besler, Gary Gerstenecker, Renliang Zhang, Xin Min Li, Anthony J. DiDonato, Valentin Gogonea, W.H. Wilson Tang, Jonathan D. Smith, Edward F. Plow, Paul L. Fox, Diana M. Shih, Aldons J. Lusis, Edward A. Fisher, Joseph A. DiDonato, Ulf Landmesser, and Stanley L. Hazen

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Thermodynamic Characterization of Five Key Kinetic Parameters That Define Neuronal Nitric Oxide Synthase Catalysis, Mohammad Mahfuzul Haque, Jesus Tejero, Mekki Bayachou, Zhi-Qiang Wang, Mohammed Fadlalla, and Dennis J. Stuehr

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Membrane Mimetic Surface Functionalization of Nanoparticles: Methods and Applications, Jacob Weingart, Pratima Vabbilisetty, and Xue-Long Sun

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Development and Characterization of A Non-natural Nucleoside that Displays Anticancer Activity Against Solid Tumors, Jackelyn Golden, Edward A. Motea, Xuemei Zhang, Jung-Suk Choi, Ye Feng, Yan Xu, Irene Lee, and Anthony J. Berdis

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Inhibition of Metastasis by HEXIM1 Through Effects on Cell Invasion and Angiogenesis, W. Ketchart, Kerri M. Smith, T. Krupka, B. M. Wittmann, Y. Hu, P. A. Rayman, Y. Q. Doughman, J. M. Albert, X. Bai, J. H. Finke, Yan Xu, A. A. Exner, and M. M. Montano

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Synthesis and Anticancer Mechanism Investigation of Dual Hsp27 and Tubulin Inhibitors, Bo Zhong, Snigdha Chennamaneni, Rati Lama, Xin Yi, Werner J. Geldenhuys, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, and Bin Su Ph.D.

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Synthesis and Anticancer Mechanism Investigation of Dual Hsp27 and Tubulin Inhibitors, Bo Zhong, Snigdha Chennamaneni, Rati Lama, Xin Yi, Werner J. Geldenhuys, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, and Bin Su

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Logger Rhythm, David W. Ball

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A Phase 1 Study of TRC102, An Inhibitor of Base Excision Repair, and Pemetrexed in Patients with Advanced Solid Tumors, Michael S. Gordon, Lee S. Rosen, David Mendelson, Ramesh K. Ramanathan, Jonathan Goldman, Lili Liu, Yan Xu, Stanton L. Gerson, Stephen P. Anthony, William D. Figg, Shawn Spencer, Bonne J. Adams, Charles P. Theuer, Bryan R. Leigh, and Glen J. Weiss

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Polymerized Hemin as An Electrocatalytic Platform for Peroxynitrite's Oxidation and Detection, Serban F. Peteu, Tiyash Bose, and Mekki Bayachou

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The Low-Resolution Structure of Nascent High Density Lipoprotein Reconstituted with DMPC With and Without Cholesterol Reveals A Mechanism for Particle Expansion, Valentin Gogonea, Gary S. Gerstenecker, Zhiping Wu, Xavier Lee, Celalettin Topbas, Matthew A. Wagner, Thomas C. Tallant, Jonathan D. Smith, Phil Callow, Vitaliy Pipich, Helen Malet, Guy Schoehn, Joseph A. DiDonato, and Stanley L. Hazen

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Why is the Sky Blue?, James A. Locke and David W. Ball

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Bio-Inspired Liposomal Thrombomodulin Conjugate through Bio-Orthogonal Chemistry, Hailong Zhang, Jacob Weingart, Rui Jiang, Jianhao Peng, Qingyu Wu, and Xue-Long Sun

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Insights Into The Roles of Desolvation and π-Electron Interactions During DNA Polymerization, Edward A. Motea, Irene Lee, and Anthony J. Berdis

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Development, Validation and Pilot Screening of An In Vitro Multi-Cellular Three-Dimensional Cancer Spheroid Assay for Anti-Cancer Drug Testing, Rati Lama, Lin Zhang, Janine M. Naim, Jennifer Williams, Aimin Zhou, and Bin Su

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Design and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with A Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-Lactamase, Marisa L. Winkler, Elizabeth A. Rodkey, Magdalena A. Taracila, Sarah M. Drawz, Christopher R. Bethel, Krisztina M. Papp-Wallace, Kerri M. Smith, Yan Xu, Jeffrey R. Dwulit-Smith, Chiara Romagnoli, Emilia Caselli, Fabio Prati, Focco van den Akker, and Robert A. Bonomo

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Wien’s Displacement Law as a Function of Frequency, David W. Ball

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Spectroscopic Analysis of Polymerization and Exonuclease Proofreading By A High-Fidelity DNA Polymerase During Translesion DNA Synthesis, Babho Devadoss, Irene Lee, and Anthony J. Berdis

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Charge-Pairing Interactions Control The Conformational Setpoint and Motions of The FMN Domain in Neuronal Nitric Oxide Synthase, Mohammad Mahfuzul Haque, Mekki Bayachou, Mohammed A. Fadlalla, Deborah Durra, and Dennis J. Stuehr

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Synthesis and Evaluation of Some 17-Acetamidoandrostane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity Studies, Yanmin Huang, Jianguo Cui, Linyi Jia, Chunfang Gan, Huacan Song, Chun Zeng, and Aimin Zhou

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Metastable Nanostructured Metallized Fluoropolymer Composites for Energetics, Hannah A. Miller, Bradley S. Kusel, Seth T. Danielson, James W. Neat, Eryn K. Avjian, Scott N. Pierson, Stephen M. Budy, David W. Ball, Scott T. Iacono, and Sharon C. Kettwich

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Peroxynitrite Activity of Hemin-Functionalized Reduced Graphene Oxide, Raluca Oprea, Serban F. Peteu, Palaniappan Subramanian, Wang Qi, Emmanualle Pichonat, Henri Happy, Mekki Bayachou, Rabah Boukherroub, and Sabine Szunerits

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Voltage-Controlled Enzyme-Catalyzed Glucose–Gluconolactone Conversion Using A Field-Effect Enzymatic Detector, Siu Tung Yau, Yan Xu, Yang Song, Ye Feng, and Jiapeng Wang

Submissions from 2012

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Quantities, Symbols, and Units in Spectroscopy, David W. Ball

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Evaluating the Therapeutic Potential of A Non-Natural Nucleotide That Inhibits Human Ribonucleotide Reductase, Md. Faiz Ahmad, Qun Wan, Shalini Jha, Edward Motea, Anthony J. Berdis, and Chris Dealwis

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COX Inhibitors Indomethacin and Sulindac Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Mechanism Investigation, Snigdha Chennamaneni, Bo Zhong, Rati Lama, and Bin Su

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The Association of Elevated 2′,5′-Oligoadenylate-Dependent RNase L with Lung Cancer Correlated with Deficient Enzymatic Activity and Decreased Capacity of RNase L Dimerization, Huijing Yin, Aimin Zhou, and Yalei Dai

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Exploring The Role of A Conserved Class A Residue in The Ω-Loop of KPC-2 β-Lactamase: A Mechanism For Ceftazidime Hydrolysis

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Development and Validation of A Rapid LC-MS/MS Method forTthe Determination of JCC76, A Novel Antitumor Agent for Breast Cancer, in Rat Plasma and Its Application to A Pharmacokinetics Study, Xiaohan Cai, Bo Zhong, Bin Su, Songlin Xu, and Baochuan Guo

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RNase L Controls Terminal Adipocyte Differentiation, Lipids Storage and Insulin Sensitivity via CHOP10 mRNA Regulation, O. Fabre, T. Salehzada, K. Lambert, Y. Boo Seok, Aimin Zhou, J. Mercier, and C. Bisbal

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Identification of Selective Tubulin Inhibitors as Potential Anti-Trypanosomal Agents, Rati Lama, Ranjodh Sandhu, Bo Zhong, Bibo Li, and Bin Su

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Understanding The Molecular Determinants of Substrate and Inhibitor Specificities in The Carbapenemase KPC-2: Exploring The Roles of Arg220 and Glu276

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Aminonitrocyclopropanes as Possible High-Energy Materials. Quantum Chemical Calculations, Joshua M. Halstead, Jessica N. Whittaker, and David W. Ball

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Development and Validation of An LC–MS/MS Method for Pharmacokinetic Study of Methoxyamine in Phase I Clinical Trial, Shuming Yang, Panayiotis Savvides, Lili Liu, Stanton L. Gerson, and Yan Xu

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Nucleoside Transporters: Biological Insights and Therapeutic Applications, Jung-Suk Choi and Anthony J. Berdis

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6-Hydroximino-4-Aza-A-Homo-Cholest-3-One and Related Analogue as A Potent Inducer of Apoptosis in Cancer Cells, Yanmin Huang, Jianguo Cui, Qiaoxia Zheng, Chun Zeng, Quan Chen, and Aimin Zhou

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Liposomal Glyco-Microarray for Studying Glycolipid–Protein Interactions, Yong Ma, Irena Sobkiv, Valentinas Gruzdys, Hailong Zhang, and Xue-Long Sun

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Recent Advances in Sialic Acid-Focused Glycomics, Huan Nie, Yu Li, and Xue-Long Sun

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Maxwell's Equations, Part VII, David W. Ball

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Structure and Thermodynamic Properties of Nitroformic Acid, Nitroformyl Nitrate, and Ammonium Nitroformate, David W. Ball

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Human Sperm DNA Oxidation, Motility and Viability in The Presence of l-Carnitine During in Vitro Incubation and Centrifugation, S. Banihani, R. Sharma, Mekki Bayachou, E. Sabanegh, and A. Agarwal

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Insufficient Radiofrequency Ablation Promotes Angiogenesis of Residual Hepatocellular Carcinoma Via HIF-1α/VEGFA, Jian Kong, Jinge Kong, Bing Pan, Shan Ke, Shuying Dong, Xiuli Li, Aimin Zhou, Lemin Zheng, and Wen Bing Sun

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Introducing NOB-NOBs: nitrogen-oxygen-boron cycles with potential high-energy properties, Aloysus K. Lawong and David W. Ball

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Immobilized Sialyloligo-Macroligand and Its Proein Binding Specificity, Satya Nandana Narla and Xue-Long Sun

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Identification of A Class of Novel Tubulin Inhibitors, Xin Yi, Bo Zhong, Kerri M. Smith, Werner J. Geldenhuys, Ye Feng, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, and Bin Su

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Glyco-Macroligand Microarray with Controlled Orientation and Glycan Density, Satya Nandana Narla and Xue-Long Sun

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Maxwell's Equations, Part VI, David W. Ball

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BON-BONs: Cyclic Molecules with a Boron-Oxygen-Nitrogen Backbone. Computational Studies of Their Thermodynamic Properties, Aloysus K. Lawong and David W. Ball

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Solid-state Mechanical Properties of Crystalline Drugs and Excipients, Shravan Singh Thakur, Manik Pavan Kumar Maheswaram, Dhruthiman Reddy Mantheni, Lakshmi Kaza, Indika Perara, David W. Ball, John Moran, and Alan T. Riga

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Thermally-induced Dielectric Relaxation Spectra in Three Aldohexose Monosaccharides, Libby Yoerg, M. Ellen Matthews, Lakshmi Kaza, Naullage Indika Perera, David W. Ball, John Moran, and Alan T. Riga

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Carbohydrate-Protein Interactions and Their Biosensing Applications, Xiangqun Zeng, Cesar A.S. Andrade, Maria D.L. Oliveira, and Xue-Long Sun

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Chemoselectively Surface Funtionalizable Tethered Bilayer Lipid Membrane for Versatile Membrane Mimetic Systems Fabrication, Yong Ma, Rui Jiang, Hailong Zhang, Valentinas Gruzdys, and Xue-Long Sun

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A Non-Natural Nucleoside with Combined Therapeutic and Diagnostic Activities Against Leukemia, Edward A. Motea, Irene Lee, and Anthony J. Berdis

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End-Point Immobilization of Recombinant Thrombomodulin via Sortase-Mediated Ligation, Rui Jiang, Jacob Weingart, Hailong Zhang, Yong Ma, and Xue-Long Sun

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Probe Functionalization With A Rhop-3 Antibody: Toward A Rhop-3 Antigen Immunosensor For Detection of Malaria, Salaam Saleh, Susan Moreno Molek, Perera N. Indika, Alan Riga, Tobili Sam Yellowe, and Mekki Bayachou

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Tissue Sample Preparation in Bioanalytical Assays, Kerri M. Smith and Yan Xu

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Recent Advances in the Synthesis and Biomedical Applications of Chain-End Functionalized Glycopolymers, Satya Nandana Narla, Huan Nie, Yu Li, and Xue-Long Sun

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Gold-Containing Indoles as Anticancer Agents That Potentiate The Cytotoxic Effects of Ionizing Radiation, Sandra Craig, Lei Gao, Irene Lee, Thomas Gray, and Anthony J. Berdis

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A Better Ion Fraction for a Neutral Aqueous Solution, David W. Ball

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Maxwell's Equations, Part V, David W. Ball

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Inhibiting Selective DNA Polymerases for Therapeutic Intervention, Anthony J. Berdis

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Removal of Uracil by Uracil DNA Glycosylase Limits Pemetrexed Cytotoxicity: Overriding the Limit with Methoxyamine to Inhibit Base Excision Repair, A. D. Bulgar, L. D. Weeks, Y. Miao, S. Yang, Yan Xu, C. Guo, S. Markowitz, N. Oleinick, S. L. Gerson, and Lili Liu

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Synthesis and Antitumour Activities of A Novel Class of Dehydroabietylamine Derivatives, Yong Chen, Zhong Xiang Lin, and Aimin Zhou

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A New Novel Mutation in FBN1 Causes Autosomal Dominant Marfan Syndrome in A Chinese Family, Jiamei Dong, Juan Bu, Wei Du, Yuan Li, Yanlei Jia, Jianchang Li, Xiaoli Meng, Minghui Yuan, Xiaojuan Peng, Aimin Zhou, and Lejin Wang

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Development of A ‘Clickable’ Non-Natural Nucleotide to Visualize The Replication of Non-Instructional DNA Lesions, Edward A. Motea, Irene Lee, and Anthony J. Berdis

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Quantitative Measurement of the Solvent Accessibility of Histidine Imidazole Groups in Proteins, Vennela Mullangi, Xiang Zhou, David W. Ball, David J. Anderson, and Masaru Miyagi

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Synthesis of 1,3-Diphenyl-6-alkyl/aryl-Substituted Fulvene Chromophores: Observation of π–π Interactions in a 6-Pyrene-Substituted 1,3-Diphenylfulvene, Andrew J. Peloquin, Rebecca L. Stone, Sarah E. Avila, Erlyn R. Rudico, Christopher B. Horn, Kim A. Gardner, David W. Ball, Jane E.B. Johnson, Scott T. Iacono, and Gary J. Balaich

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Nitric Oxide Synthase Encapsulation in Liposomes: A Potential Delivery Platform to (Nitric Oxide)-Deficient Targets, Reshani H. Perera, Pubudu M. Peiris, Serban F. Peteu, and Mekki Bayachou

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Capillary Electrophoresis in Clinical Chemistry, Simuli L. Wabuyele and Yan Xu

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From COX-2 Inhibitor Nimesulide to Potent Anti-Cancer Agent: Synthesis, In Vitro, In Vivo and Pharmacokinetic Evaluation, Bo Zhong, Xiaohan Cai, Snigdha Chennamaneni, Xin Yi, Lili Liu, John J. Pink, Afshin Dowlati, Yan Xu, Aimin Zhou, and Bin Su

Submissions from 2011

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Maxwell's Equations, Part IV, David W. Ball

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Synthesis and Antiproliferative Activity of Some Steroidal Lactams, Yanmin Huang, Jianguo Cui, Sijing Chen, Chunfang Gan, and Aimin Zhou

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Azide-Reactive Liposome for Chemoselective and Biocompatible Liposomal Surface Functionalization and Glyco-Liposomal Microarray Fabrication, Yong Ma, Hailong Zhang, Valentinas Gruzdys, and Xue-Long Sun

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Towards New Green High Energy Materials. Computational Chemistry on Nitro-Substituted Urea, Rachelle R. Wagner and David W. Ball

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Investigation of Nitric Oxide Synthase (NOS) Redox and Catalytic Activity in Electrospun Fibers, Bhagya Gunasekera, Tamara Lubysheva, Tiyash Bose, Timothy Kantz, Michael Russo, Haitham F. Kalil, Gary Wnek, and Mekki Bayachou

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Nitrospiropentanes as Potential High Energy Materials, Rachelle R. Wagner and David W. Ball

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Exploring The Roles of Nucleobase Desolvation and Shape Complementarity During The Misreplication of O6-Methylguanine, Delia Chavarria, Andrea Ramos Serrano, Ichiro Hirao, and Anthony J. Berdis

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Design and Synthesis of A Biotinylated Probe of COX-2 Inhibitor Nimesulide Analog JCC76, Bo Zhong, Rati Lama, Kerri M. Smith, Yan Xu, and Bin Su

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Maxwell's Equations, Part III, David W. Ball

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Intracellular Nitric Oxide Measurement in Human Sperm Using 4, 5-DiaminoFluorescein-2-Diacetate and Flow Cytometry, R. Sharma, S. Bani Hani, Mekki Bayachou, E. Sabanegh, and A. Agarwal

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Nitric Oxide Synthase (NOS) Encapsulated in Electrospun Fibers: A Novel Nitric Oxide (NO) Releasing Membrane, Bhagya Gunasekera, T. Lubysheva, G. E. Wnek, and Mekki Bayachou

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Glycosylation and Processing of Pro-B-Type Natriuretic Peptide in Cardiomyocytes, Jianhao Peng, Jingjing Jiang, Wei Wang, Xiaofei Qi, Xue-Long Sun, and Qingyu Wua

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Determination of Hexamethylene Bisacetamide, An Antineoplastic Compound, in Mouse and Human Plasma by LC–MS/MS, Kerri M. Smith, Wannarasmi Ketchart, Xiang Zhou, Monica M. Montano, and Yan Xu

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In Vitro and In Vivo Effects of A Cyclooxygenase-2 Inhibitor Nimesulide Analog JCC76 in Aromatase Inhibitors-Insensitive Breast Cancer Cells, Bo Zhong, Xiaohan Cai, Xing Yi, Aimin Zhou, Shiuan Chen, and Bin Su